Aled Roberts

Job Title: Postdoctoral Research Scientist
Telephone No:  + 44 (0) 29 2041 6459
Email Address:   aerobats@cardiffmet.ac.uk 
Room Number: D2.02

 

 

Research​

 My current research focusses on the treatment of opportunistic pathogens associated with pulmonary disease, more specifically those that persist to form chronic infections of the cystic fibrosis (CF) lung. Using manuka honey alone, and in combination with a range of therapeutic agents, we have shown excellent inhibitory efficacy against a range of CF pathogens, such as; Burkholderia, Pseudomonas, Stenotrophomonas, Achromobacter, and Staphylococcus to name but a few of the genera studied. Previous research has focussed on the conflict and cooperation of bacterial cells in mixed communities, the diversity of cells from a seemingly clonal population, and the spatial structure of small bacterial aggregates, and larger biofilms.  Further to this, I have extensively the mechanistic effects of manuka honey on P. aeruginosa growth, virulence, and biofilm formation.  

Publications

 

  • Roberts, A. E. L., Brown, H. L., & Jenkins, R. E. (2015). On the antibacterial effects of manuka honey: mechanistic insights. Research and Reports in Biology. 6
  • Roberts, A. E. L., Kragh, K. N., Bjarnsholt, T., & Diggle, S. P. (2015). The Limitations of In Vitro Experimentation in Understanding Biofilms and Chronic Infection. Journal of Molecular Biology. 
  • Harrison, F., Roberts, A. E. L., Gabrilska, R., Rumbaugh, K. P., Lee, C., & Diggle, S. P. (2015). A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity. mBio, 6(4).
  • Melaugh, G., Hutchison, J., Kragh, K. N., Irie,Y., Roberts, A. E. L., Bjarnsholt, T., Diggle, S. P. D., Gordon, V., & Allen, R. J. (2015) Shaping the growth of bacterial aggregates in biofilms. Biological Physics, 
  • Roberts, A. E. L., Maddocks, S. E., & Cooper, R. A. (2015). Manuka honey reduces the motility of Pseudomonas aeruginosa by suppression of flagella-associated genes. The Journal of Antimicrobial Chemotherapy, 70(3), 716–725
  • Roberts, A. E. L., Maddocks, S. E., & Cooper, R. A. (2012). Manuka honey is bactericidal against Pseudomonas aeruginosa and results in differential expression of oprF and algD. Microbiology, 158(12), 3005–3013.

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