Dr Claire Kelly

​Dr Claire Kelly

Job Title:            Lecturer in Biomedical Science
Room No:          D2.01E
Telephone No:  +44 (0) 29 2020 5995
Email Address:  ckelly@cardiffmet.ac.uk

 






Teaching

I teach on a number of undergraduate programmes within the department of Biomedical Sciences including Healthcare Science, Biomedical Science and Biomedical Sciences (Health, Exercise and Nutruition).

Modules I deliver include: the final year Project module, Contemporary topics in Biomedical Sceince, Pathophysiology of Disease, Physiology Pharmacology and Toxicology, Human physiology and endocrinology as well as basic neuroscience and neuroanatomy to biomedical scientists. In addition, I also supervise both undergraduate and postgraduate level student projects in my specialist area of neuroscience. 

Undergraduate

APS6022 – Research Project (Module Leader)

APS6008 – Contemporary topics

APS5017 – Physiology, Pharmacology and Toxicology (Module Leader)

SBM5001- Pathophysiology of Disease

SBM5005 – Sports Biomechanics and Functional Anatomy

APS4022 – Human Anatomy and Physiology

APS3007 – Human Biology

APS3012 – Research methods (Key Skills module)

Postgraduate

MBS7010 - Dissertation


I also supervise PhD students:

Current Cardiff Metropolitan University students:

Eleftheria Kodosaki


Research

My background is in neuroscience and my research interest comes under the theme of cell replacement therapy in neurodegenerative diseases.

I have a long-standing interest in cell transplantation as a therapy for neurodegenerative diseases such as Parkinson's disease and Huntington's disease.  My research in this area has been largely in animal models of these diseases, although I have also had a major role in establishing an ethically approved human fetal tissue supply for the clinical application of this work and have had extended training in GMP technology. My PhD was a study of neural stem cells as a donor source for Huntington's disease and provided me with experience of both rodent and human fetal neural stem cells.  Since then, I have continued to research neural stem cells, but have also gained experience with ES cell and iPS cell derived neural precursors, and in particular, I have been involved in the neural transplantation of such cells.  I am also extremely interested in characterising the in vitro culture system in which cells are grown, using molecular techniques to identify genes of interest and manipulation of culture systems to obtain the desired cell type.

I have played a key role in the development of a novel animal model for the preclinical assessment of human donor cells for neural transplantation.  The model provides a novel strategy for allowing human cells to be xenotransplanted into the rodent brain without the need for immunosuppression.  I would like to advance this work by undertaking a detailed characterisation of this system as well as by understanding the underlying immunological mechanism of the model. Following from this the role of inflammation in Huntington's disease is of great importance and may have important implications for therapeutic interventions, not least the ability of transplanted cells to survive in an inflamed environment. Understanding of the inflammatory pathways in Huntington's disease from pre-clinical through to clinical stage disease is increasing and deciphering the pathways involved in mediating this process is of particular interest. The communication between the periphery and central nervous system is important and how this influences on other pathophysiological process known to be ongoing in HD is still largely unknown. Finding ways to target this aspect of the disease once mechanisms are fully understood could have important implications for other therapeutics, which together could have a greater beneficial effect for the patient.  

Publications

  • Precious SV, Zietlow R, Dunnett SB, Kelly CM, Rosser AE. Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease? (Neurochemistry International 2017 accepted)
  • Precious SV and Kelly CM. Transplantation in HD – Are we transplanting the right cells? (Book chapter, In Tech publishers. In press)
  • Precious SV*, Kelly CM*, Vinh NN, Pekarik V, Scherf C, Penketh RJ, Amso NN, Dunnett SB and Rosser AE. Characterisation of FoxP1 as a marker of striatal medium spiny neurons and their precursors. Experimental Neurology 2016
  • Sophie V Precious, Claire M Kelly, Nicholas D Allen & Anne E Rosser. Can manipulation of differentiation conditions eliminate proliferative cells from a population of ES cell-derived forebrain cells? Neurogenesis, 2016. DOI: 10.1080/23262133.2015.1127311
  • Lelos MJ, Morgan RJ, Kelly CM, Torres EM, Rosser AE, Dunnett SB. Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease. Exp Neurol. 2016 Apr; 278:54-61
  • Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Vinh NN, Sun Yung, Kelly CM, Svendsen C, Kemp P, Arjomand J, Schoenfeld R, Alberch J, Allen ND, Rosser AE, Canals JM. Quantitative high throughput gene expression profiling of human striatal development to screen stem cells derived medium spiny neurons. (Mol Ther Methods Clin Dev. 2015 Sep 16;2:15030).
  • Roberton VH, Rosser AE, Kelly CM. Neonatal desensitization for the study of regenerative medicine. Regenerative Medicine 2015, 10(3):265-74
  • Charles Arber, Sophie V. Precious, Serafí Cambray, Jessica R. Risner-Janiczek, Claire Kelly, Zoe Noakes, Andreas Heuer, Mark A. Ungless, Tristan A. Rodríguez, Anne E. Rosser, Stephen B. Dunnett ,Meng Li. Activin A directs striatal projection  neuron differentiation of human pluripotent stem cells Development 2015 Apr1:142(7):1375-86.
  • Rinaldi F, Hartfield E, Crompton LA, Kelly CM, Rosser AE, James B Uney, Maeve A Caldwell. Cross regulation of gap junction Connexin43 and b-catenin influences differentiation of human neural progenitor cells. Cell Death and Disease 2014 Jan 23
  • Roberton VH, Evans AE, Harrison DJ, Precious SV, Dunnett SB, Kelly CM, Rosser AE.Is the adult mouse striatum a hostile host for neural transplant survival.  Neuroreport. 2013 Dec 18;24(18).
  • Heuer A, Lelos MJ, Kelly CM, Torres EM, Dunnett SB. Dopamine-rich grafts alleviate deficits in contralateral response space induced by extensive dopamine depletion in rats. Exp Neurol. 2013 Sep; 247:485-95.
  • Zietlow Rike , Precious Sophie V, Kelly Claire M, Dunnett Stephen Ba, Rosser Anne E Long-term expansion of human fetal neural progenitors leads to reduced graft viability in the neonatal rat brain. Exp Neurol. 2012 Jun;235(2):563-73
  • Evans A, Kelly CM, Precious SV, and Rosser AE. Molecular regulation of striatal development. Anat Res Int. 2012; 2012:106529
  • Kelly CM, and Rosser AE. Cellular Therapies in Huntington's Disease. Huntington's Disease (2012), ISBN 979-953-307-066-6.
  • Kelly CM, Precious SV, Torres EM, Harrison A, Williams D, Scherf C, Weyrauch U, Lane E, Penketh R, Amso NN, Kemp P, Dunnett SB and Rosser AE. Medical termination of pregnancy: a viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation; 2011;20(4):503-13
  • Oscar Cordero-Llana, Sarah Scott, Sarah Maslen, Jane Anderson, Julia Boyle, Ruma Raha-Chowhdury, Pam Tyers, Roger Barker, Claire Kelly, Anne Rosser, Elaine Stephens, Siddharthan Chandran, and Maeve Caldwell. Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells. Cell Death and Differentiation 2011, May;18(5):907-13.
  • Rosser AE, Kelly CM, Dunnett SB. Cell transplantation for Huntington's disease: practical and clinical considerations. Future Neurology (2011), Vol. 6 No.1; 45-62
  • Kelly CM, Precious SV, Scherf C, Penketh R, Amso N, Battersby A, Allen ND, Dunnett SB, Rosser AE. Neonatal tolerisation allows long-term survival of neuroanl xenortransplants without chronic immunosuppression. Nature Methods (2009) Apr;6(4):271-3
  •  Kelly CM, Handley O, Rosser AE. Human Trials for Neurodegenerative disease.  In: Neil J. Scolding and David Gordon (eds.), Methods Mol Biol. 2009;549:33-47. © Humana Press
  • Kelly CM, Dunnett SB, Rosser AE. Medium Spiny neurons for transplantation in Huntington's Disease. Biochemical Society Transactions (2009) Volume 37, part 1
  • Paynter SJ, Andrews KJ, Vinh NN, Kelly CM, Rosser AE, Amso NN, Dunnett SB. Membrane permeability coefficients of murine primary neural brain cells in the presence of cryoprotectant. Cryobiology. 2009; Jun; 58(3): 308-14.
  • Kelly CM, Precious SV, Penketh R, Amso N, Dunnett SB, Rosser AE.  Striatal graft projections are influenced by donor cell type and not the immunogenic background.  Brain, 2007;130:1317-1329.
  • Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain, 2007;130:1263-1275.

External Links

BNA (British Neuroscience Association)

Anatomical Society

RSB

Scientific advisory committee for Ataxia UK.

Review for Neurological Research, Experimental Neurology, Neuropsychopharmacology and the MRC

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