Dr Claire Kelly

Job Title:            Lecturer in Biomedical Science
Room No:          D2.01E
Telephone No:  +44 (0) 29 2041 5995
Email Address:  ckelly@cardiffmet.ac.uk

 

Teaching

Human physiology, pharmacology and endocrinology as well as basic neuroscience and neuroanatomy to biomedical scientists. I am also year 1 Tutor.

Research

My background is in neuroscience and my research interest comes under the theme of cell replacement therapy in neurodegenerative diseases.

I have played a key role in the development of a novel animal model for the preclinical assessment of human donor cells for neural transplantation.  The model provides a novel strategy for allowing human cells to be xenotransplanted into the rodent brain without the need for immunosuppression.  I would like to advance this work by undertaking a detailed characterisation of this system as well as by understanding the underlying immunological mechanism of the model.

I have a long standing interest in cell transplantation as a therapy for neurodegenerative diseases such as Parkinson’s disease and Huntington’s disease.  My research in this area has been largely in animal models of these diseases, although I have also had a major role in establishing an ethically approved human fetal tissue supply for the clinical application of this work and have had extended training in GMP technology.

My PhD was a study of neural stem cells as a donor source for Huntington’s disease provided experience of both rodent and human fetal neural stem cells.  Since then, I have continued to research neural stem cells, but have also gained experience with ES cell and iPS cell derived neural precursors, and in particular I have been involved in the neural transplantation of such cells.  I am also extremely interested in characterising the in vitro culture system in which cells are grown, using molecular techniques to identify genes of interest and manipulation of culture systems to obtain the desired cell type.

Publications

Evans AE, Harrison DJ, Openshaw RL 1, Roberton VH, Leadbetter A, Heuer A, Lelos MJ, Kelly CM, Saleh L, Dunnett SB, Brooks SPM, Rosser AE. Conditional Knock out of cortical Foxp1 in the mouse results in an ADHD phenotype. (submitted).

Precious SV*, Kelly CM*, Vinh NN, Pekarik V, Scherf C, Penketh RJ, Amso NN, Dunnett SB and Rosser AE. Characterisation of FoxP1 as a marker of striatal medium spiny neurons and their precursors. (J Neursocience)

Charles Arber, Sophie V. Precious, Serafí Cambray, Jessica R. Risner-Janiczek, Claire Kelly, Zoe Noakes, Andreas Heuer, Mark A. Ungless, Tristan A. Rodríguez, Anne E. Rosser, Stephen B. Dunnett  and Meng Li. Activin A directs striatal projection neuron differentiation of human pluripotent stem cells (Accepted Development)

Rinaldi F, Hartfield E, Crompton LA, Kelly CM, Rosser AE, James B Uney, Maeve A Caldwell. Cross regulation of gap junction Connexin43 and b-catenin influences differentiation of human neural progenitor cells. Cell Death and Disease 2014 Jan;23

Roberton VH, Evans AE, Harrison DJ, Precious SV, Dunnett SB, Kelly CM, Rosser AE. Is the adult mouse striatum a hostile host for neural transplant survival. Neuroreport. 2013 Dec 18;24(18).

Heuer A, Lelos MJ, Kelly CM, Torres EM, Dunnett SB. Dopamine-rich grafts alleviate deficits in contralateral response space induced byextensive dopamine depletion in rats. Exp Neurol. 2013 Sep; 247:485-95.

Kelly CM, Battersby A, Rosser AE. Stem cell transplantation for neurodegenerative disease: a distant dream? Aging Health (2013) April; 9 (2):139-148

Zietlow Rike , Precious Sophie V, Kelly Claire M, Dunnett Stephen B, Rosser Anne E. Long-term expansion of human fetal neural progenitors leads to reduced graft viability in the neonatal rat brain. Exp Neurol. 2012 Jun;235(2):563-73

Evans A, Kelly CM, Precious SV, and Rosser AE. Molecular regulation of striatal development. Anat Res Int. 2012; 2012:106529

Kelly CM, and Rosser AE. Cellular Therapies in Huntington’s Disease. Huntington’s Disease (2012), ISBN 979-953-307-066-6.

Kelly CM, Precious SV, Torres EM, Harrison A, Williams D, Scherf C, Weyrauch U, Lane E, Penketh R, Amso NN, Kemp P, Dunnett SB and Rosser AE. Medical termination of pregnancy: a viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation; 2011;20(4):503-13

Oscar Cordero-Llana, Sarah Scott, Sarah Maslen, Jane Anderson, Julia Boyle, Ruma Raha-Chowhdury, Pam Tyers, Roger Barker, Claire Kelly, Anne Rosser, Elaine Stephens, Siddharthan Chandran, and Maeve Caldwell. Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells. Cell Death and Differentiation 2011, May;18(5):907-13.

Rosser AE, Kelly CM, Dunnett SB. Cell transplantation for Huntington’s disease: practical and clinical considerations. Future Neurology (2011), Vol. 6 No.1; 45-62

Kelly CM, Precious SV, Scherf C, Penketh R, Amso N, Battersby A, Allen ND, Dunnett SB, Rosser AE. Neonatal tolerisation allows long-term survival of neuroanl xenortransplants without chronic immunosuppression. Nature Methods (2009) Apr;6(4):271-3

Kelly CM, Handley O, Rosser AE. Human Trials for Neurodegenerative disease.  In: Neil J. Scolding and David Gordon (eds.), Methods Mol Biol. 2009;549:33-47. © Humana Press

Kelly CM, Dunnett SB, Rosser AE. Medium Spiny neurons for transplantation in Huntington’s Disease. Biochemical Society Transactions (2009) Volume 37, part 1

Paynter SJ, Andrews KJ, Vinh NN, Kelly CM, Rosser AE, Amso NN, Dunnett SB. Membrane permeability coefficients of murine primary neural brain cells in the presence of cryoprotectant. Cryobiology. 2009; Jun; 58(3): 308-14.

Kelly CM, Precious SV, Penketh R, Amso N, Dunnett SB, Rosser AE.  Striatal graft projections are influenced by donor cell type and not the immunogenic background.  Brain, 2007;130:1317-1329.

Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain, 2007;130:1263-1275.

Kelly CM, Dunnett SB, Rosser AE. Cell-based therapy for Huntington’s Disease. In: P.R.Sanberg CDDa, editor. Cell Therapy for Brain Repair. Vol 1. Totowa: Humana Press Inc, 2006:83-117

Kelly CM, Tyers P, Borg MT, Svendsen CN, Dunnett SB, Rosser AE. EGF and FGF-2 responsiveness of rat and mouse neural precursors derived from the embryonic CNS. Brain Research Bulletin. 2005;15:83-94

Kelly CM, Zietlow R, Dunnett SB, Rosser AE. The effects of various concentrations of FGF-2 on the proliferation and neuronal yield of murine embryonic neural precursor cells in vitro.  Cell Transplantation, 2003;12(3):215-223

External Links

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