Dr Rachel Adams

This information is currently being updated.

Research interests are centred around the aetiology and pathophysiology of circulatory disease.  Specific interests include:
• The role of white cells in decreased blood flow, the inflammatory cascade and damage to the vascular endothelium.
• The effect of inflammatory stimuli on flow of blood cells in the microcirculation
• Interactions between white blood cells and the vascular endothelium
• The role of inflammatory mediators (such as arachidonic acid metabolites, neutrophil elastase, oxygen radicals and adhesion molecules) in cell activation and decreased cell deformability in diseases including peripheral vascular disease, aortic surgery, venous disease and diabetes.
• The development and use of mathematical models to describe the flow of blood cells through the microcirculation.

Selected Publications

Adams RA, Al-Mosawi, A, Berube KA and Evans S-A (2008) A The effect of intratracheal instillation of particulate air pollution into rats on blood polymorphonucleocyte and monocyte actin polymerisation. Blood, submitted.
 
Evans, S-A, Al-Mosawi, A, Adams, RA, and Berube, KA (2006) Inflammation, edema, and peripheral blood changes in lung-compromised rats after instillation with combustion-derived and manufactured nanoparticles. Exp Lung Res, 32, 363-378.

Hughes SF, Cotter MJ, Evans SA, Jones KP, and Adams RA (2006) Role of leucocytes in damage to the vascular endothelium during ischaemia-reperfusion injury. British journal of biomedical science 63: 166-170, 2006.

Singh N, Webb R, Adams R, Evans, SA, Al-Mosawi, A, Evans, M, Roberts, AW and Thomas, AW (2005) The PPAR-gamma activator, Rosiglitazone, inhibits actin polymerisation in monocytes: Involvement of Akt and intracellular calcium. Biochemical and Biophysical Research Communications; 333:455-462

Blann AD, Adams R, Ashleigh R, Naser S, Kirkpatrick U and McCollum CN (2001) Changes in endothelial, leucocyte and platelet markers following contrast medium injection during angiography in patients with peripheral artery disease. Brit J Radiol 74:811-817

Evans SA, Adams RA, Rainger G Ed (2001) Monocytes are a rheologically heterogenous popultation of cells. Clin Hemorheol Micro 25:63-73

Kirkpatrick UJ, Blann AD, Adams RA and McCollum CN (2000) Soluble adhesion molecules in clinical ischaemic injury. Int J Surg Investig 2:151-158

Evans SA, Adams RA, Nash GB (1999) What do measurements of filterability of blood tell us about the effect of red cell aggregation on flow resistance in small vessels? Biorheology 36:453-455

Jones JG, Adams RA, Cook AM and Evans SA (1999) Examination of a rheological profile for blood using micropore filters. British Journal of Haematology 104: 100-108

Kirkpatrick, U.J., Adams, R.A., Lardi A & McCollum, C.N. (1998) Rheological properties and function of blood cells in stored bank blood and salvaged blood. British Journal of Haematology 101:364-373

Richard, S., Seigneur, M., Blann, A., Adams, R.A., Renard, M., Puntous, M., Boiron, J-M., Amiral, J., Reiffers, J., & Boisseau, M. (1996). Vascular endothelial lesion in patients undergoing bone marrow transplantation. Bone Marrow Transplantation 18: 955-959

Adams,R.A., Jones,J.G., Evans,S-A,Cook,A.M (1996) Red blood cell filterability through nickel & polycarbonate filters. Clin Hemorheol 16: 813-814

Blann,A.D., Seigneur,M., Adams,R.A., & McCollum C.N. (1996) Neutrophil elastase, von Willebrand factor, soluble thombomodulin and percutaneous oxygen in peripheral athero-sclerosis. Eur J Vasc Endovasc Surg 12: 218-222

Blann, A.D., Adams, R.A., Katai, F., Ashleigh, R., & Taberner, D.A. (1996) Haematology and coagulation indices in paired samples of arterial and venus blood from patients with arterial disease. Haemostasis 26: 72-78

Adams, R.A., Evans, S-A, & Jones, J.G. (1995) The effects of temperature on the filtration of diluted blood through 3m and 5m membranes. Biorheology 32: 643-653

Adams, R.A., Evans S-A & Jones, J.G. (1994) Characterization of leukocytes by filtration of diluted blood. Biorheology 31: 603-615

Jones, J.G., Adams, R.A. & Evans, S-A. (1994) Bulk filtration through micropore membranes for analysing blood cell rheology in clinical research. Clinical Hemorheology 14: 149-169