Dr Sarah Maddocks

 Job Title:            Lecturer
Room No:           D2.01f
Telephone No:  + 44 (0) 29 2041 5607
Email Address:   smaddocks@cardiffmet.ac.uk




Microbiology at foundation, BSc and MSc levels


The mainstay of my research is to investigate processes involved in the host-pathogen relationship as infection ensues. This includes characterisation of bacterial adhesions, transcriptional regulators, quorum sensing and virulence gene expression. I also use biofilm models to ascertain the effect of individual host environmental stimuli, such as iron restriction, on the developing microbial community and use in vitro models to determine the impact this might have during infection. A different branch of my research focuses on novel antimicrobials and their efficacy against healthcare associated pathogens. Part of these studies are concerned with identifying antimicrobial targets to determine a mode of action and facilitate most appropriate use within the clinical environment, with the aim of preventing the emergence of strains that might exhibit resistance.  I have ongoing research collaborations with Dr. Kevin Purdy (University of Warwick), Dr Andrew Collins and Dr Michele Barbour (University of Bristol), and Prof Simon Andrews (Reading University).


Selected publications
1. Kronda JM, Cooper RA, Maddocks SE (2013) Manuka honey inhibits siderophore production in Pseudomas aeruginosa. J Applied Microbiology 115: 86-90

2. Maddocks SE, Jenkins RE, Rowlands RS, Purdy KJ, Cooper RA (2013) Manuka honey inhibits adhesion and invasion of medically important bacteria in vitro. Future Microbiology 8: 1523-36 doi: 10.2217/fmb.13.126

3. Maddocks SE & Jenkins RE (2013) Honey: a sweet solution to the growing problem of antimicrobial resistance? Future Microbiology 8: 1419-1429

4. Barbour ME, Maddocks SE, Wood NJ, Collins AR (2013) Synthesis, characterisation and efficacy of antimicrobial chlorexidine hexametaphosphate nanoparticles for applications in biomedical materials and consumer products. International Journal of Nanomedicine 8: 3507-3519

5. Franklin L, Nobbs AH, Bricio-Moreno L, Wright CJ, Maddocks SE, Sahota JS, Ralph J, O'Connor M, Jenkinson HF, Kadioglu A (2013) The AgI/II family adhesion AspA is required for respiratory infection by Streptococcus pyogenes. PLoS One 8: e62433

6. Roberts AEL, Maddocks SE, Cooper RA (2012) Manuka honey is bactericidal against Pseudomonas aeruginosa and results in different expressions of oprF and algD. Microbiology 158: 3005-3013

7. Green AE, Rowlands RS, Cooper RA, Maddocks SE (2012) The effect of the flavonol morin on adhesion and aggregation of Streptococcus pyogenes. FEMS Letters Microbiology 333: 54-58

8. Maddocks SE, Salinas Lopez M, Rowlands RS, Cooper RA (2012) Manuka honey inhibits the development of Streptococcus pyogenes biofilms and causes reduced expression of two fibronectin binding proteins. Microbiology 158: 781-790

9. Maddocks SE, Wright CJ, Nobbs AH, Brittan JL, Franklin L, Stromberg N, Kadioglu A, Jepson MA, Jenkinson HF (2011) Streptococcus pyogenes antigen I/II family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation. Molecular Microbiology 81: 1034-1049

10. Brady LJ, Maddocks SE, Larson MR, Forsgren N, Persson K, Deivanayagam CC, Jenkinson HF (2010) The changing faces of Streptococcus AgI/II polypeptide adhesins. Molecular Microbiology 77: 276-286

11. Maddocks SE and Oyston PCF (2008 Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins. Microbiology 154: 3609-3623

12. Cartron ML, Maddocks S, Gillingham P, Craven C and Andrews SC (2006) Feo: transport of ferrous iron into bacteria. Biometals 19: 143-157

13. Roberts, A. L., Maddocks, S. E., Copper, R. A. (2014) Manuka honey reduces the motility of Pseudomonas aeruginosa by suppression of flagella-associated genes Journal of Antimicrobial Chemotherapy (Accepted for publication).

14. Maddocks, S. E., Barbour, M. E. and Collins, A. M (2014) Nanoparticle technology to deliver effective antimicrobials (Editorial). American Journal of Microbiology 5: 35-36

15. Ripley, D. A., Morris, R. H. and Maddocks, S. E. (2014) Dual stimulation with bacterial and viral components increases the expression of hepcidin in human monocytes. FEMS Microbiology Letters DOI: 10.1111/1574-6968.12553