My research focuses on adipocyte-derived extracellular vesicles (EVs) as novel communicators of adipose tissue. EVs are submicron vesicles released from multiple cell types under both physiological and pathophysiological conditions. My work looks into characterising EVs released from adipocytes under normal and stressful conditions (e.g. hypoxia), and the potential interactions of these EVs with other cell types, including macrophages and endothelial cells.
Connolly KD, Willis GR, Datta DB, Ellins EA, Ladell K, Price DA, Guschina IA, Rees DA, James PE. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. J Lipid Res, Volume 55, 10 October 2014 pp.2064-2072
Willis GR, Connolly K, Ladell K, Davies TS, Guschina IA, Ramji D, Miners K, Price DA, Clayton A, James PE, Rees DA. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Hum Reprod, Volume 29, 12 December 2014 pp.2756-2763
Connolly KD, Guschina IA, Yeung V, Clayton A, Draman MS, Von Ruhland C, Ludgate M, James PE, Rees DA. Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis.
Journal of Extracellular Vesicles, 2015.