Prof Jorge Erusalimsky, PhD, FRSB

Job Title: Professor of Biomedical Sciences
Room No: D2.11a
Telephone No:+ 44 (0) 29 2041 6853
Email Address:jderusalimsky@cardiffmet.ac.uk


 


 



 

Teaching

This information is currently being updated.

Research

Jorge has been carrying out research on the cellular and molecular mechanisms that underlie the relationship between ageing and cardiovascular diseases for over fifteen years. His work in this area was among the first to demonstrate the occurrence of vascular cell senescence in vivo. He has also investigated the roles that telomere integrity, telomerase activity, oxidative stress and growth factors play in the control of endothelial cell replicative capacity. His current research in this area focuses on the modulation of vascular cell senescence by stress-response proteins and on biomarkers of vascular ageing. In addition, Jorge has a long standing interest in the the biology of megakaryocyte differentiation and platelet production.  He has published over seventy  five peer-reviewed articles.

For further details on Jorge's current research see the Cellular Senescence and Vascular Biology Group.

At Cardiff Met Jorge has also been involved in many research-related enabling and managerial activities, including;

    • Acting as the Cardiff School of Health Sciences Associate Dean of Research and as Chair of the Cardiff School of Health Sciences Ethics Committee (2014-2015)
    • Serving as a member of Cardiff Metropolitan University Intellectual Property Panel (2009-present)
    • Designing and launching the new Cardiff School of Health Sciences Biomedical Research Laboratories (2007-2009) 

 

Publications

Jorge has published over 75 peer review articles. A selection of key publications from the last ten years is shown below:

Erusalimsky J.D., Grillari J., Grune T., Jansen-Duerr P. Lippi G., Sinclair A.J., Tegner J., Vina J., Durrance-Bagale A., Minambres R., Viegas M., Rodriguez-Manas L. (2015) In search of 'omics'-based biomarkers to predict the risk of frailty and its consequences in older individuals: The FRAILOMIC initiative Gerontology 62, 182-190

Ahluwalia M., Butcher L., Donovan H., Killick-Cole C., Jones P. M. and Erusalimsky J. D. (2015) The gene expression signature of anagrelide provides and insight into its mechanism of action and uncovers new regulators of megakaryopoiesis J. Thromb. Haemost  13, 1103-1112

Villalobos L.A., Uryga A., Romacho T., Leivas A., Sánchez-Ferrer C.F., Erusalimsky J.D. and Peiró C. (2014) Visfatin/Nampt induces telomere damage and senescence in human endothelial cells Int. J. Cardiol. 175, 573-575.

Zalli A., Carvalho L., Lin  J., Hamer M., Erusalimsky J.D., Blackburn E.H. and Steptoe A. (2014) Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources Proc. Natl. Acad. Sci. USA 111, 4519-4524.

Cardus A., Uryga A., Walters G. and Erusalimsky J.D. (2013) SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction and senescence. Cardiovasc. Res. 97, 571-579.

Brydon L., Lin  J., Butcher L., Hamer M., Erusalimsky J.D., Blackburn E.H. and Steptoe A. (2012) Hostility and cellular aging in men from the Whitehall II cohort. Biol. Psychiatry 71, 767-773.

Steptoe A., Hamer M., Butcher L., Lin J., Brydon L., Kivimaki M., Marmot M., Blackburn E. and Erusalimsky J.D. (2011) Educational attainment but not current socioeconomic status is associated with leukocyte telomere length. Brain Behav. Immun. 25, 1292-1298.

Ahluwalia M., Donovan H., Singh N., Butcher L. and Erusalimsky J.D. (2010) Anagrelide represses GATA-1 and FOG-1 expression without interfering with thrombopoietin receptor signal transduction. J. Thromb. Haemost. 8, 2252-2261.

Debacq-Chainiaux F., Erusalimsky J.D., Campisi J. and Toussaint O. (2009) Methods to detect senescence-associated beta-galactosidase (SA-bGAL) activity, a biomarker of senescent cells in culture and in vivo. Nature Protoc. 4, 1798-1806.

Erusalimsky J.D. (2009) Vascular endothelial senescence: From mechanisms to pathophysiology. J. Appl. Physiol. 106, 326-332.

Erusalimsky J.D. and Moncada S. (2007) Nitric oxide and mitochondrial signaling: From Physiology to Pathophysiology. Arterioscler. Thromb. Vasc. Biol. 27, 2524-2531.

Steptoe A., Gibson L., Vuononvirta R., Hamer M., Wardle J., Rycroft J.A., Martin J.F. and Erusalimsky J.D. (2006) The effects of chronic tea intake on platelet activation and inflammation: a double blind placebo controlled trial. Atherosclerosis 193, 277-282.

Hong Y., Wang G., Gutierrez del Arroyo A., Hernandez J., Skene C. and Erusalimsky J.D. (2006) Comparison between anagrelide and hydroxycarbamide in their activities against haematopoietic progenitor cell growth and differentiation: Selectivity of anagrelide for the megakaryocytic lineage. Leukemia 20, 1117-1122.

External Links

Visiting and Honorary Professorships

Honorary Professor, University College London, London, UK (2006-2015)
Visiting Professor, Department of Pharmacology and Therapeutics, Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain (2011-2013)
Visiting Professor, Department of Immunology IDEHU, University of Buenos Aires, Argentina (2012)

Learned Societies and Professional Organizations

Fellow of the Royal Society of Biology
Member of the British Society for Cardiovascular Research
Member of the British Society for Research on Ageing
Founding Member of the Association of Argentine Professionals in the UK (APARU), joint coordinator for the areas of Science and Technology between 2003 and 2006

Expert Reviewing Panels and Advisory Committees

Austrian Science Fund (2003-07), BBSRC (UK), British Cardiac Society, British Heart Foundation, European Society of Cardiology, Inserm (France), International Society on Thrombosis and Haemostasis, Medical Research Council (UK), Wellcome Trust (UK), Netherlands Cardiovascular Research Initiative (CVON)
Advisory Committee for International Programmes of Scientific and Technological Cooperation, Argentine Ministry for Science, Technology and Productive Innovation (2011-2013)​
Ramon y Cajal Fellowship Committee, Spanish Ministry of Economy and Competitiveness (2016)

Editorial Board of Scientific Journals

Gerontology
NPG Aging and Mechanisms of Disease

European Commission FP7-funded partnerships

The FRAILOMIC Initiative (2012-2017)
WhyWeAge (2009-2011)