Please see our open applications for KESS2 Scholarships, please ensure you have checked the eligibility criteria prior to applying which can be found in the above dropdown list.
Isolation & Purification of bioactive peptides from protease treated bovine milk protein (whey protein and β-casein) to develop biotechnologies and process technologies for scaled up production of peptide-containing products with health benefits.
Deadline: 31st May 2018
There is a significant body of published evidence indicating that milk proteins, particularly their hydrolysates, have a potential to form the basis for the development of novel functional food ingredients. To date, very few dairy companies have fully capitalised on this potential. Some of the generic benefits of casein and whey protein hydrolysate include their ease of digestion and their content of bioactive peptides, many of which can confer health benefits above and beyond the normal nutritional impact.
The aim of the research project is to develop technologies to derive bioactive peptides from bovine milk proteins (whey and casein). The peptides will be analysed and subjected to fractionation and the fractions of interest will undergo further enrichment processing. The ultimate aim is to apply the developed protocols and process bio/technologies for scaled up production of the resulting peptide-containing products. The peptide enrichment selected is anticipated to form the basis of products with particular health benefits.
The project will provide the successful candidate with an exciting opportunity to work across academia and industry. The project supervisory team will be comprised of academic members of staff from Cardiff Metropolitan University department of Healthcare and Food, part of the School of Sport & Health Sciences, and industrial supervisors from Volac International Ltd. The student will carry out research and development at Cardiff Metropolitan University’s Llandaff campus and at Volac International, Port Talbot, where they will use and develop skills in a number of biotechnological, process technology and protein analysis techniques as well as developing communications and project management skills.
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Isolation and Purification of glycomacropeptide (GMP) from whey on industrial scale for its use as a bioactive compound to improve human health.
Deadline: 31st May 2018
Whey protein is an important and valuable source of high quality protein and bioactive compounds. Whey protein concentrates and isolates have been in the market for some time and used, especially by athletes, to aid as a nutritional supplement for muscle growth and recovery. Whey protein is also rich in branched chain amino acids (BCAA) which are important for improving protein synthesis especially for patients with liver failure.
GMP is an important (64 amino acids peptide) constituent in whey. Published work indicates GMP’s nutritional and bioactivity potential for improving metabolism, neutralising bacterial and viral enterotoxins and for enhancing the immune system. In addition, the absence of the aromatic amino acid, phenylalanine (PA) means that it can be used for patients with the metabolic disorder phenylketoneuria (PKU). Other reported health benefits include the stimulation of fat and protein digestion and it’s bifidogenic effect, encouraging the growth of probiotics, with associated immunological health benefits.
The main emphasis of this project is to isolate and purify GMP for these well-recognised health benefits. Our research has previously isolated and used GMP for its potential as a mineral binding peptide to minimise dental erosion. The main aim of this project is to further isolate GMP from whey using chromatographic techniques. This will produce specific purified peptide as supplements and as active ingredients in food formulations. We envisage that this project will lead to the development of innovative, scalable technologies and products for both the ingredients and consumer markets.
The project will provide the successful candidate with an exciting opportunity to work across academia and industry. The project supervisory team will be comprised of academic members of staff from Cardiff Metropolitan University department of Healthcare and Food, part of the School of Sport & Health Sciences, industrial supervisors from Volac International Ltd and external experts. The student will carry out research and development at Cardiff Metropolitan University’s Llandaff campus and at Volac International, Port Talbot, where they will use and develop skills in a number of biotechnological, process technology and protein analysis techniques as well as developing communications and project management skills.
For more information please click here.
“Health by Stealth”: An evidenced-based intervention to evaluate exercise as a vehicle to engage homeless young men in psychological interventions to improve their health and wellbeing.
Deadline: 1st June 2018
The proposed programme of research will be an innovative pilot research project to design and test the effectiveness of a bespoke, trauma informed, psychological intervention delivered in conjunction with physical exercise. The physical exercise will take the form of strength and conditioning training (gym work) and aims to engage young men, as this group have historically proved the most difficult to engage for Llamau.
The intervention is aimed at young men with multiple complex needs who have disengaged from support services, putting them at high risk of homelessness. Young men currently using the Llamau services have reported that gym sessions would be their preferred exercise activity. Delivering a psychological intervention in conjunction with physical exercise is an innovative idea and, it is hoped, will increase the re-engagement of young people in services. If this is the outcome, we expect there to be a positive impact on physical and psychological health as well as preventing homelessness. The project is consistent with the Public Health Wales plan to ensure that, ‘Wherever possible focus efforts on ensuring that, from the earliest possible age, individuals are supported to follow a health benefiting and crime free life course that allows them to realise their full potential.’ (Bellis et al. 2015:21)
Exercise itself is known to have a positive impact on mental health, in particular depression and anxiety, and has been shown to help build self-esteem (Upton and Thirlaway 2011; Hardman & Stensel 2009). McGale, McArdle & Gaffney (2012) report that an integrated exercise/CBT mental health promotion for men was perceived to increase physical skill, social support, positive affect and generate changes in daily behaviour. This project will combine exercise (specifically strength & conditioning training) with goal setting, motivation and resiliency training in a non-clinical environment. This ‘health by stealth’ approach is hoped will help hard-to-reach young men to improve mental and physical wellbeing and reduce involvement with negative or harmful coping mechanisms.
For more information please click here.