Dr Chris Pugh

Chris Pugh

​Lecturer​ in Exercise Physiology

Telephone number: 029 2020 5293
Email address: cjpugh@cardiffmet.ac.uk

Chris is a lecturer in Exercise Physiology who joined Cardiff Metropolitan University in 2014. He spent 6-years at Liverpool John Moores University where he completed his undergraduate degree and PhD thesis entitled "Vascular and Metabolic Adaptations to Exercise in Non-Alcoholic Fatty Liver Disease". In 2012, Chris moved to Australia for a Post-Doctoral research fellowship at the University of Western Australia, where he utilised cutting-edge techniques to investigate acute and chronic vascular adaptations to exercise.  As part of his role at Cardiff Metropolitan University, Chris continues to utilise these techniques to conduct novel research and deliver a research-lead teaching syllabus.​

Research / Publications

Chris has a keen interest in exploring the therapeutic effect of exercise on cardiovascular disease (CVD) in vulnerable clinical populations. His research focuses on acute and chronic vascular adaptations to exercise and other physiological stressors such as water immersion, heat exposure, negative pressure and supplementation with a view to promote non-pharmacological interventions to reduce CVD risk in clinical populations.

Areas of research focus and technical expertise include:

  • Conduit artery function via Doppler ultrasound
  • Cutaneous microvascular function via laser Doppler & intradermal microdialysis
  • Cerebral blood flow via Transcranial Doppler
  • Thermoregulatory control via core/skin thermometry and sweat rate production
  • Muscle sympathetic nerve activity via microneurography

Chris has fostered strong collaborative links with numerous research institutes across the globe, conducted large multi-centre clinical trials, secured both internal and external research funds (~£120,000) and produced numerous high-impact journal publications.

List of Publications

Carter, H.H., Spence, A.L., Pugh, C.J.A., Ainslie, P.H., Naylor, L.H., Green, D.J. Cardiovascular responses to water immersion in humans: Impact on cerebral perfusion. Differential impact of water immersion on arterial blood flow and shear stress in the carotid and brachial arteries of humans. Physiological Reports; 5(10): e13285, 2017.

Pugh, J.D., Pugh, C.J.A., Savulescu, J. Exercise prescription and the doctor's duty of non-maleficence. British Journal of Sports Medicine. Epub ahead of print; doi: 10.1136/bjsports-2016-097388, 2017.

Black, J.M., Stohr, E.J., Stone, K., Pugh, C.J.A., Stembridge, M., Shave, R., Esformes, J.I. The effect of an acute bout of resistance exercise on carotid artery strain and strain rate. Physiological Reports; 4 (17): e12959, 2016

Pugh C.J.A, Sprung VS, Jones H, Richardson P, Shojaee-Moradie F, Umpleby AM, Green DJ, Cable NT, Trenell MI, Kemp GJ, Cuthbertson DJ. Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in non-alcoholic fatty liver disease (NAFLD). International Journal of Obesity; 40: 1927-1930, 2016.

Cuthbertson, D.J., Shoajee-Moradie, F., Sprung, V.S., Jones. H., Pugh, C.J.A., Richardson, P., Kemp, G.J., Barrett, M., Jackson, N.C., Thomas, E.L., Bell, J.D., Umpleby, A.M. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease. Clinical Science; 130: 93-104, 2016.

Pugh, C.J.A., Sprung, V.S., Ono, K., Spence, A.L., Thijssen, D.H.J., Carter, H.H., Green, D.J. The impact of water immersion during exercise on cerebral blood flow. Medicine and Science in Sport and Exercise;47: 299-306, 2015.

Pugh CJ, Sprung VS, Kemp GJ, Richardson P, Shojaee-Moradie F, Umpleby AM, Green DJ, Cable NT, Jones H, and Cuthbertson DJ. Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease. American J Physiology; Heart & Circulatory Physiology 307: 1298-1306, 2014.

Green, D.J., Eijsvogels, T., Bouts, Y., Maiorana, A., Naylor, L.H., Scholten, R., Pugh, C.J.A., Sprung, V.S., Schreuder, T., Jones, H., Cable, N.T., Hopman, M.T.E., Thijssen, D.H.J. Factors predicting the impact of exercise training on vascular health in humans: A pooled analysis of responders and non-responders. Journal of Applied Physiology 117: 345-352, 2014.

Thijssen, D.H.J., Atkinson, C.L., Ono, K., Sprung, V.S., Spence, A.L., Pugh, C.J.A., Green, D.J. Sympathetic nervous system activation, arterial shear rate and flow mediated dilation. Journal of Applied Physiology 116: 1300-1307, 2014.

Carter, H.H., Spence, A.L., Atkinson, C.L., Pugh, C.J.A., Cable, N.T., Thijssen, D.H.J., Naylor, L.H., Green, D.J. Distinct impacts of skin blood flow and temperature on cutaneous microvascular adaptation in humans. Medicine and Science in Sport and Exercise; 46: 2113–2121, 2014.

Cuthbertson, D.J. Irwin, A., Pugh, C.J.A., Jones. H., Sprung, V.S., Daousi, C., Adam, V.L., Bimson, W.E., Shoajee-Moradie, F., Umpleby, A.M., Wilding, J.P., Kemp, G.J. Ectopic lipid storage in Non-Alcoholic Fatty Liver Disease is not mediated by impaired mitochondrial oxidative phosphorylation in skeletal muscle. Clinical Science; 127: 655-663, 2014.

Carter, H.H., Spence, A.L., Pugh, C.J.A., Ainslie, P.H., Naylor, L.H., Green, D.J. Cardiovascular responses to water immersion in humans: Impact on cerebral perfusion. American Journal of Physiology Regulatory, Integrative and Comparative Physiology; 306: R636–R640, 2014.

Pugh C.J.A., Cuthbertson, D.J., Sprung, V.S., Kemp, G.J., Richardson, P., Umpleby, A.M., Green, D.J., Cable, N.T., Jones. H. Exercise training improves cutaneous microvascular function in non-alcoholic fatty liver disease. American Journal of Physiology: Endocrinology & Metabolism, 305, E50-58, 2013.

Carter, H.H., Spence, A.L., Atkinson, C.L., Pugh, C.J.A., Naylor, L.H., Green, D.J. Repeated core temperature elevation induces conduit artery adaptation in humans. European Journal of Applied Physiology; 114(4): 859-65, 2013.

Sprung, V.S., Cuthbertson, D.J., Pugh, C.J.A., Atkinson, G., Aziz, N., Kemp, G.J., Green, D.J., Cable, N.T., Jones H. Nitric-oxide mediated cutaneous microvessel function is impaired in PCOS women and can be improved with exercise training. The Journal of Physiology, 15;591, 1475-87, 2013.

Sprung, V.S., Jones. H., Pugh, C.J.A., Aziz, N., Kemp, G.J., Green, D.J., Atkinson, G., Cable, N.T., Cuthbertson, D.J. Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition. Clinical Science, 126, 67-74, 2013.

Sprung, V.S., Cuthbertson, D.J., Pugh, C.J.A., Aziz, N., Kemp, G.J., Daousi, C., Atkinson, G., Green, D.J., Cable, N.T., Jones, H. Exercise Training in PCOS Enhances FMD in the Absence of Changes in Fatness. Medicine and Science in Sport and Exercise, 45(12):2234-42, 2013.

Mills, A., Rosenberg, M., Stratton. G., Carter, H.H., Spence, A.L., Pugh, C.J.A., Green, D.J., Naylor, L.H. The effect of exergaming on vascular function in children. Journal of Pediatrics, 163(3):806-10, 2013

Hopkins, N.D., Cuthbertson, D.J, Kemp, G.J., Pugh, C.J.A., Green, D.J., Cable, N.T., Jones, H. Effects of 6 months glucagon-like peptide-1 (GLP-1) receptor agonists treatment on endothelial function in patients type 2 diabetes mellitus. Diabetes, Obesity and Metabolism, 15(8), 770-773, 2013.

Sprung, V.S., Atkinson, G., Cuthbertson, D.J., Pugh, C.J.A., Aziz, N., Green, D.J., Cable, N.T., & Jones, H. Endothelial Function measured using Flow Mediated Dilation in Polycystic Ovarian Syndrome: A meta-analysis. Clinical Endocrinology (Oxf), 78, 438-446, 2012.

Jones, H., Sprung, V.S., Pugh, C.J.A., Daousi, C., Irwin, A., Aziz, N., Adams, V.L., Thomas, E.L., Bell, J.D., Kemp, G.J., & Cuthbertson, D.J. Polycystic Ovary Syndrome with hyperandrogenism is characterised by an increased risk of hepatic steatosis, compared to non-hyperandrogenic PCOS phenotypes and healthy controls, independent of obesity. Journal of Clinical Endocrinology and Metabolism, 97(10), 3709-16, 2012.

Atkinson, G., Pugh, C., & Scott, M. A. Exploring data distribution prior to analysis: Benefits and pitfalls. Int J Sports Med, 31(12), 841-842, 2010.

Teaching and Supervision

Teaching

Chris is currently the module leader for Advanced Exercise Physiology & Health (SSP6015) and co-lead for Cardiovascular Exercise Physiology (SSP7108). He also delivers on all undergraduate and postgraduate modules that relate to cardiovascular physiology, thermoregulation and clinical exercise prescription. Chris is a Level 4 and 5 personal tutor and supervises numerous Level 6 & 7 dissertation projects that relate to cardiovascular function during exercise

PhD Supervision

Denis Wakeham (Director of Studies): The effect of age and cardiorespiratory fitness status on the sympathetic regulation of vascular tone.

Zavia Incledon (Co-Supervisor): The effect of anti-histamine administration on post exercise hypotension.

External Links

Chris collaborates with numerous researchers across the world, including scientists from the following institutions:

  • University of Western Australia, Perth, Australia
  • Liverpool John Moores University, Liverpool, UK
  • Radboud University MC, Nijmegen, Netherlands
  • University Hospital Wales, Cardiff, UK
  • Bangor University, Bangor, UK
  • University of South Wales, Pontypridd, UK