Dr Chris Pugh

 

​Lecturer​ in Exercise Physiology

Telephone number: 029 2020 5293
Email address: cjpugh@cardiffmet.ac.uk

Chris is a lecturer in Exercise Physiology who joined Cardiff Metropolitan University in 2014. He spent 6-years at Liverpool John Moores University where he completed his undergraduate degree and PhD thesis entitled "Vascular and Metabolic Adaptations to Exercise in Non-Alcoholic Fatty Liver Disease". In 2012, Chris moved to Australia for a Post-Doctoral research fellowship at the University of Western Australia, where he utilised cutting-edge techniques to investigate acute and chronic vascular adaptations to exercise.  As part of his role at Cardiff Metropolitan University, Chris continues to utilise these techniques to conduct novel research and deliver a research-lead teaching syllabus.​

Research / Publications

I have a keen interest in exploring the therapeutic effect of exercise on cardiovascular disease (CVD) in vulnerable clinical populations. My research focuses on acute and chronic vascular adaptations to exercise and other physiological stressors such as water immersion, heat exposure, ischaemic preconditioning, negative pressure and supplementation with a view to promote non-pharmacological interventions to reduce CVD risk in clinical populations.

Areas of research focus and technical expertise include:

  • Conduit artery function via Doppler ultrasound
  • Cutaneous microvascular function via laser Doppler & intradermal microdialysis
  • Cerebral blood flow via Transcranial Doppler
  • Thermoregulatory control via core/skin thermometry and sweat rate production

List of Publications

Pugh CJA, Sprung VS, Green DJ, Timothy Cable N, Jones H, Cuthbertson DJ, Kemp GJ, Richardson P, Shojaee-Moradie F, Margot Umpleby A. (2014). Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease. American Journal of Physiology - Heart and Circulatory Physiology, 307(9), H1298-H1306.

Pugh, C.J.A., Sprung, V.S., Ono, K., Spence, A.L., Thijssen, D.H.J., Carter, H.H., Green, D.J. (2014). The impact of water immersion during exercise on cerebral blood flow. Medicine and Science in Sport and Exercise. E-pub ahead of print.

Green, D.J., Eijsvogels, T., Bouts, Y., Maiorana, A., Naylor, L.H., Scholten, R., Pugh, C.J.A., Sprung, V.S., Schreuder, T., Jones, H., Cable, N.T., Hopman, M.T.E., Thijssen, D.H.J. (2014) Factors predicting the impact of exercise training on vascular health in humans: A pooled analysis of responders and non-responders. Journal of Applied Physiology, 117(4), 345-352.

Thijssen, D.H.J., Atkinson, C.L., Ono, K., Sprung, V.S., Spence, A.L., Pugh, C.J.A., Green, D.J. (2014). Sympathetic nervous system activation, arterial shear rate and flow mediated dilation. Journal of Applied Physiology, 116, 1300-1307.

Carter, H.H., Spence, A.L., Atkinson, C.L., Pugh, C.J.A., Cable, N.T., Thijssen, D.H.J., Naylor, L.H., Green, D.J. (2014). Distinct impacts of skin blood flow and temperature on cutaneous microvascular adaptation in humans. Medicine and Science in Sport and Exercise, 46(11), 2113-21..

Cuthbertson, D.J. Irwin, A., Pugh, C.J.A., Jones. H., Sprung, V.S., Daousi, C., Adam, V.L., Bimson, W.E., Shoajee-Moradie, F., Umpleby, A.M., Wilding, J.P., Kemp, G.J (2014). Ectopic lipid storage in Non-Alcoholic Fatty Liver Disease is not mediated by impaired mitochondrial oxidative phosphorylation in skeletal muscle. Clinical Science, 127(11-12), 655-663.

Carter, H.H., Spence, A.L., Pugh, C.J.A., Ainslie, P.H., Naylor, L.H., Green, D.J. (2014). Cardiovascular responses to water immersion in humans: Impact on cerebral perfusion. American Journal of Physiology Regulatory, Integrative and Comparative Physiology; 306: R636–R640.


Pugh C.J.A., Cuthbertson, D.J., Sprung, V.S., Kemp, G.J., Richardson, P., Umpleby, A.M., Green, D.J., Cable, N.T., Jones. H. (2013). Exercise training improves cutaneous microvascular function in non-alcoholic fatty liver disease. American Journal of Physiology: Endocrinology & Metabolism, 305, E50-58.

Carter, H.H., Spence, A.L., Atkinson, C.L., Pugh, C.J.A., Naylor, L.H., Green, D.J. (2013). Repeated core temperature elevation induces conduit artery adaptation in humans. European Journal of Applied Physiology; 114(4): 859-65.

Sprung, V.S., Cuthbertson, D.J., Pugh, C.J.A., Atkinson, G., Aziz, N., Kemp, G.J., Green, D.J., Cable, N.T., Jones H. (2013). Nitric-oxide mediated cutaneous microvessel function is impaired in PCOS women and can be improved with exercise training. The Journal of Physiology, 15;591 (Pt 6), 1475-87.

Sprung, V.S., Jones. H., Pugh, C.J.A., Aziz, N., Kemp, G.J., Green, D.J., Atkinson, G., Cable, N.T., Cuthbertson, D.J. (2013). Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition. Clinical Science, 126, 67-74.

Sprung, V.S., Cuthbertson, D.J., Pugh, C.J.A., Aziz, N., Kemp, G.J., Daousi, C., Atkinson, G., Green, D.J., Cable, N.T., Jones, H. (2013). Exercise Training in PCOS Enhances FMD in the Absence of Changes in Fatness. Medicine and Science in Sport and Exercise, 45(12):2234-42.

Mills, A., Rosenberg, M., Stratton. G., Carter, H.H., Spence, A.L., Pugh, C.J.A., Green, D.J., Naylor, L.H. (2013). The effect of exergaming on vascular function in children. Journal of Pediatrics, 163(3):806-10.

Hopkins, N.D., Cuthbertson, D.J, Kemp, G.J., Pugh, C.J.A., Green, D.J., Cable, N.T., Jones, H. (2013). Effects of 6 months glucagon-like peptide-1 (GLP-1) receptor agonists treatment on endothelial function in patients type 2 diabetes mellitus. Diabetes, Obesity and Metabolism, 15(8), 770-773.

Sprung, V.S., Atkinson, G., Cuthbertson, D.J., Pugh, C.J.A., Aziz, N., Green, D.J., Cable, N.T., & Jones, H. (2012). Endothelial Function measured using Flow Mediated Dilation in Polycystic Ovarian Syndrome: A meta-analysis. Clinical Endocrinology (Oxf), 78, 438-446.

Jones, H., Sprung, V.S., Pugh, C.J.A., Daousi, C., Irwin, A., Aziz, N., Adams, V.L., Thomas, E.L., Bell, J.D., Kemp, G.J., & Cuthbertson, D.J. (2012). Polycystic Ovary Syndrome with hyperandrogenism is characterised by an increased risk of hepatic steatosis, compared to non-hyperandrogenic PCOS phenotypes and healthy controls, independent of obesity. Journal of Clinical Endocrinology and Metabolism, 97(10), 3709-16.

Atkinson, G., Pugh, C., & Scott, M. A. (2010). Exploring data distribution prior to analysis:
Benefits and pitfalls. Int J Sports Med, 31(12), 841-842.

Pugh, C.J.A., Sprung, V.S., Ono, K., Spence, A.L., Thijssen, D.H.J., Carter, H.H., Green, D.J. (2013). The impact of water immersion during exercise on cerebral perfusion. Journal of Science and Medicine in Sport,16, 6, S33.

Pugh, C. J.A., Jones, H., Sprung, V. S., Kemp, G. J., Irwin, A., Adams, V. L., et al. (2011). A 16-week moderate intensity exercise intervention reduces body mass, hepatic triglyceride and abdominal subcutaneous fat in NAFLD patients. Journal of Diabetes, 3, S1, p201.

Pugh, C. J., Jones, H., Sprung, V. S., Kemp, G. J., Irwin, A., Adams, V. L., et al. (2010). Exercise-induced reduction in liver fat is accompanied by improvements in vascular function in non-alcoholic fatty liver disease. Diabetologia, 53, S30.

Teaching and Supervision

I am currently the module leader for Advanced Sport & Exercise Physiology (SSP6055), and Physical Activity, Health & Special Populations (SSP5061). I also deliver on all undergraduate and postgraduate modules that relate to cardiovascular physiology, thermoregulation and clinical exercise prescription. I am a Level 4 personal tutor as well as a Level 4 and Level 5 laboratory coordinator. I also supervise numerous Level 6 dissertation projects that relate to cardiovascular function during exercise.

Qualifications and Awards

  • PhD, Liverpool John Moores University, Liverpool, UK
  • BSc, Liverpool John Moores University, Liverpool, UK
  • Associate Fellow of the Higher Education Academy

External Links

  • I collaborate with numerous researchers across the world, including scientists from the following institutions:

    • University of Western Australia, Perth, Australia
    • Liverpool John Moores University, Liverpool, UK
    • Radboud University MC, Nijmegen, Netherlands
    • University Hospital Aintree, Liverpool, UK
    • University of Surrey, Surrey, UK