Dr David Pugh

Name Chris Pugh

Position Senior Lecturer in Exercise Physiology

Telephone number: 02920 205239

Email address cjpugh@cardiffmet.ac.uk




 

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Profile
Chris is a Senior Lecturer in Exercise Physiology within the School of Sport and Health Sciences, who joined Cardiff Metropolitan University in 2014. He spent 6-years at Liverpool John Moores University where he completed his undergraduate degree and PhD entitled "Vascular and Metabolic Adaptations to Exercise in Non-Alcoholic Fatty Liver Disease". In 2012, Chris moved to Australia for a Post-Doctoral research fellowship at the University of Western Australia, where he utilised cutting-edge techniques to investigate acute and chronic vascular adaptations to exercise.  As part of his role at Cardiff Metropolitan University, Chris continues to utilise these techniques to conduct novel research and deliver a research-lead exercise science syllabus.

Chris' global research agenda focusses on how regular exercise and physical activity can effectively prevent and treat cardiovascular and metabolic diseases across the lifespan. He has technical expertise in numerous cutting-edge physiological techniques, which he uses to assess cardiovascular function in paediatric, elite athletic, ageing and high-risk clinical populations. These techniques include non-invasive assessment of vascular function and structure via high-resolution ultrasound, indices of cerebral blood flow via transcranial Doppler, measurement of microvessel endothelial function using intradermal microdialysis and indices of vascular sympathetic baroreflex function via microneurography. Chris supervises a team of PhD candidates who explore various aspects of his research programme and he has received in excess of £2million of competitive funding to support his research, most notably from the National Institute for Health Research, Health & Care Research Wales and the Waterloo Foundation. Chris is also the deputy lead of the Cardiovascular Physiology Research Group, as well as a member of the Centre for health, Activity & Wellbeing Research (CAWR) management committee and the School of Sport and Health Sciences Research Ethics Committee. In addition, he is the Programme Director of the Intercalated Sport & Exercise Science BSc degree and the Physiology Dissertation Co-ordinator.

 
Research Interests and Publications
Chris' research focusses on the chronic and acute effects of exercise on peripheral and cerebral vascular function across the lifespan. He utilises cutting-edge ultrasound techniques to explore the therapeutic impact of exercise training and other interventions such as heat therapy, water immersion, ischaemic preconditioning and novel pharmaceuticals in order to reduce cardiovascular disease risk in vulnerable populations. Currently, Chris' research addresses four key areas:

·        The influence of habitual exercise on healthy vascular ageing

  • The independent and combined effects of exercise training and statin therapy in the primary prevention of cardiovascular disease

·        The influence of cardiorespiratory fitness and obesity status on peripheral and cerebral vascular function across the lifespan.
·        Characterisation of the 'Athletes Artery': From power lifters to ultramarathon runners.
 
Refereed Academic Journal Articles
Talbot, J.S., Lord, R.N., Wakeham, D.J., Dawkins, T.G., Curry, B.A., Brown, M., Lodge, F.M., Pugh, C.J.A. The influence of habitual endurance exercise on carotid artery strain and strain‐rate in young and middle‐aged men. Experimental Physiology. 105: 1396-1407, 2020
 
Lord, R.N., Wakeham, D.J., Pugh, C.J.A., Simpson, L.L., Talbot, J.S., Lodge, F.M., Curry, B.A., Dawkins, T.G., Shave, R.E., Moore, J.P. The influence of barosensory vessel mechanics on the vascular sympathetic baroreflex: insights into ageing and blood pressure homeostasis. American J Physiology; Heart & Circulatory Physiology. 319 (2): H370-H376, 2020

Dawkins, T.G., Curry, B.A., Drane, A., Lord, R.N., Richards, C., Brown, M., Pugh, C.J.A., Lodge, F.M., Yousef, Z., Stembridge, M., Shave, R.E. Stimulus-specific functional remodeling of the left ventricle in endurance and resistance-trained men. American J Physiology; Heart & Circulatory Physiology https://doi.org/10.1152/ajpheart.00233.2020 [In Press]
 
Pugh, J.D., Pugh, C.J.A. Neurostimulation, doping, and the spirit of sport. Neuroethics. https://doi.org/10.1007/s12152-020-09435-7. 2020 [In Press]

Wakeham, D.J., Lord, R.N., Talbot, J.S., Curry, B., Lodge, F., Dawkins, T., Simpson, L.L., Shave, R., Moore, J.P., Pugh, C.J.A. Upward resetting of the vascular sympathetic baroreflex in middle-aged male runners. American J Physiology; Heart & Circulatory Physiology. 317:H181-H189, 2019

Pugh, C.J.A., Stone, K.J., Stöhr, E.J., McDonnell, B.J., Thompson, J.E.S., Talbot, J.S., Wakeham, D.J., Cockcroft, J.R., Shave, R. Carotid artery wall mechanics in young males with high cardiorespiratory fitness. Experimental Physiology. 103 (9): 1277-1286, 2018

 
Carter, H.H., Spence, A.L., Pugh, C.J.A., Ainslie, P.H., Naylor, L.H., Green, D.J. Differential impact of water immersion on arterial blood flow and shear stress in the carotid and brachial arteries of humans. Physiological Reports, 5 (10), e13285, 2017

Pugh, J.D., Pugh, C.J.A., Savulescu, J. Exercise prescription and the doctor's duty of non-maleficence. British Journal of Sports Medicine, 51 (21) , 1555-1556, 2017

Black, J.M., Stohr, E.J., Stone, K., Pugh, C.J.A., Stembridge, M., Shave, R., Esformes, J.I. The effect of an acute bout of resistance exercise on carotid artery strain and strain rate. Physiological Reports; 4 (17): e12959, 2016
 
Pugh C.J.A, Sprung VS, Jones H, Richardson P, Shojaee-Moradie F, Umpleby AM, Green DJ, Cable NT, Trenell MI, Kemp GJ, Cuthbertson DJ. Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in non-alcoholic fatty liver disease (NAFLD). International Journal of Obesity; 40: 1927-1930, 2016.

Cuthbertson, D.J., Shoajee-Moradie, F., Sprung, V.S., Jones. H., Pugh, C.J.A., Richardson, P., Kemp, G.J., Barrett, M., Jackson, N.C., Thomas, E.L., Bell, J.D., Umpleby, A.M. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease. Clinical Science; 130: 93-104, 2016.
 
Pugh, C.J.A., Sprung, V.S., Ono, K., Spence, A.L., Thijssen, D.H.J., Carter, H.H., Green, D.J. The impact of water immersion during exercise on cerebral blood flow. Medicine and Science in Sport and Exercise; 47: 299-306, 2015.

 
Pugh CJ, Sprung VS, Kemp GJ, Richardson P, Shojaee-Moradie F, Umpleby AM, Green DJ, Cable NT, Jones H, and Cuthbertson DJ. Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease. American J Physiology; Heart & Circulatory Physiology 307: 1298-1306, 2014.

 
Green, D.J., Eijsvogels, T., Bouts, Y., Maiorana, A., Naylor, L.H., Scholten, R., Pugh, C.J.A., Sprung, V.S., Schreuder, T., Jones, H., Cable, N.T., Hopman, M.T.E., Thijssen, D.H.J. Factors predicting the impact of exercise training on vascular health in humans: A pooled analysis of responders and non-responders. Journal of Applied Physiology 117: 345-352, 2014.
 
Thijssen, D.H.J., Atkinson, C.L., Ono, K., Sprung, V.S., Spence, A.L., Pugh, C.J.A., Green, D.J. Sympathetic nervous system activation, arterial shear rate and flow mediated dilation. Journal of Applied Physiology 116: 1300-1307, 2014.

 
Carter, H.H., Spence, A.L., Atkinson, C.L., Pugh, C.J.A., Cable, N.T., Thijssen, D.H.J., Naylor, L.H., Green, D.J. Distinct impacts of skin blood flow and temperature on cutaneous microvascular adaptation in humans.  Medicine and Science in Sport and Exercise; 46: 2113–2121, 2014.

Cuthbertson, D.J. Irwin, A., Pugh, C.J.A., Jones. H., Sprung, V.S., Daousi, C., Adam, V.L., Bimson, W.E., Shoajee-Moradie, F., Umpleby, A.M., Wilding, J.P., Kemp, G.J. Ectopic lipid storage in Non-Alcoholic Fatty Liver Disease is not mediated by impaired mitochondrial oxidative phosphorylation in skeletal muscle. Clinical Science; 127: 655-663, 2014.

Carter, H.H., Spence, A.L., Pugh, C.J.A., Ainslie, P.H., Naylor, L.H., Green, D.J. Cardiovascular responses to water immersion in humans: Impact on cerebral perfusion. American Journal of Physiology Regulatory, Integrative and Comparative Physiology; 306: R636–R640, 2014.
 
Pugh C.J.A., Cuthbertson, D.J., Sprung, V.S., Kemp, G.J., Richardson, P., Umpleby, A.M., Green, D.J., Cable, N.T., Jones. H. Exercise training improves cutaneous microvascular function in non-alcoholic fatty liver disease. American Journal of Physiology: Endocrinology & Metabolism, 305, E50-58, 2013.

Carter, H.H., Spence, A.L., Atkinson, C.L., Pugh, C.J.A., Naylor, L.H., Green, D.J. Repeated core temperature elevation induces conduit artery adaptation in humans. European Journal of Applied Physiology; 114(4): 859-65, 2013.

Sprung, V.S., Cuthbertson, D.J., Pugh, C.J.A., Atkinson, G., Aziz, N., Kemp, G.J., Green, D.J., Cable, N.T., Jones H. Nitric-oxide mediated cutaneous microvessel function is impaired in PCOS women and can be improved with exercise training. The Journal of Physiology, 15; 591, 1475-87, 2013.
 
Sprung, V.S., Jones. H., Pugh, C.J.A., Aziz, N., Kemp, G.J., Green, D.J., Atkinson, G., Cable, N.T., Cuthbertson, D.J. Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition. Clinical Science, 126, 67-74, 2013.

 
Sprung, V.S., Cuthbertson, D.J., Pugh, C.J.A., Aziz, N., Kemp, G.J., Daousi, C., Atkinson, G., Green, D.J., Cable, N.T., Jones, H. Exercise Training in PCOS Enhances FMD in the Absence of Changes in Fatness. Medicine and Science in Sport and Exercise, 45(12):2234-42, 2013.

Mills, A., Rosenberg, M., Stratton. G., Carter, H.H., Spence, A.L., Pugh, C.J.A., Green, D.J., Naylor, L.H. The effect of exergaming on vascular function in children. Journal of Pediatrics, 163(3):806-10, 2013
 
Hopkins, N.D., Cuthbertson, D.J, Kemp, G.J., Pugh, C.J.A., Green, D.J., Cable, N.T., Jones, H. Effects of 6 months glucagon-like peptide-1 (GLP-1) receptor agonists treatment on endothelial function in patients type 2 diabetes mellitus. Diabetes, Obesity and Metabolism, 15(8), 770-773, 2013.

 
Sprung, V.S., Atkinson, G., Cuthbertson, D.J., Pugh, C.J.A., Aziz, N., Green, D.J., Cable, N.T., & Jones, H. Endothelial Function measured using Flow Mediated Dilation in Polycystic Ovarian Syndrome: A meta-analysis. Clinical Endocrinology (Oxf), 78, 438-446, 2012.

Jones, H., Sprung, V.S., Pugh, C.J.A., Daousi, C., Irwin, A., Aziz, N., Adams, V.L., Thomas, E.L., Bell, J.D., Kemp, G.J., & Cuthbertson, D.J. Polycystic Ovary Syndrome with hyperandrogenism is characterised by an increased risk of hepatic steatosis, compared to non-hyperandrogenic PCOS phenotypes and healthy controls, independent of obesity. Journal of Clinical Endocrinology and Metabolism, 97(10), 3709-16, 2012.

Atkinson, G., Pugh, C., & Scott, M. A. Exploring data distribution prior to analysis: Benefits and pitfalls. Int J Sports Med, 31(12), 841-842, 2010.

Teaching and Supervision
Postgraduate Research Competitions
Zavia Inceldon: MPhil student  (Co-supervisor) - The physiological mechanisms underpinning post-exercise hypotension.
 
Postgraduate Research Students
Denis Wakeham: PhD student (Director of Studies) - The effect of age and fitness status on autonomic regulation of vascular tone.
 
Charles Steward: PhD student (Co-Supervisor) - The influence of post-exercise heating on inflammatory markers and vascular health. Registered at Coventry University.
 
Campbell Menzies: PhD student (Co-Supervisor) - The influence of post-exercise heating on exercise performance. Registered at Coventry University.

Teaching
Chris is the Programme Director of the Intercalated Sport & Exercise Science BSc degree, module leader for Exercise Physiology for Health (SSP6129) and co-lead for Cardiovascular Exercise Physiology (SSP7108). He also delivers on all undergraduate and postgraduate modules that relate to cardiovascular physiology, thermoregulation and clinical exercise prescription. He is a Level 5 personal tutor and the Physiology Dissertation Co-ordinator. In addition, Chris supervises numerous BSc and MSc dissertation projects that focus on cardiovascular physiology and exercise.

External Links
Chris collaborates with numerous researchers across the world, including scientists from the following institutions:
·        University of Western Australia, Perth, Australia
·        Liverpool John Moores University, Liverpool, UK
·        Radboud University MC, Nijmegen, Netherlands
·        Coventry University, Coventry, UK
·        University of Bristol, Bristol, UK
·        Bangor University, Bangor, UK
·        Swansea University, Swansea, UK
·        University Hospital Wales, Cardiff, UK
·        Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff, UK
·        University of Waterloo, Waterloo, Canada

Qualifications and Awards
PhD, Liverpool John Moores University, Liverpool, UK
BSc, Liverpool John Moores University, Liverpool, UK
Higher Education Academy Fellowship (FHEA), Cardiff Metropolitan University, UK.