Dr Sarah Maddocks

I teach microbiology on the Biomedical Sciences and Health Care Science BSc degree courses as well as on the MSc Biomedical Science degree course.  I am the pathway lead for the Biomedical Sciences strand of the MRes degree course.

I teach on the following modules:

• Principles and Practice of Infection Science (module leader) 
  
• Infection Science Specialism A and B (module leader)
  
• Biological and Laboratory Investigations of Disease
  
• Contemporary Topics in Biomedical Science
  
• Analytical and Diagnostic Techniques (MRes) 
  
• Research Methods in Biomedical Science (MRes)
  

My research focusses understanding the interactions between pathogens and their host during the infection process.  The overarching aim of these studies is to understand how pathogens utilise or disrupt host processes and to explore and exploit novel ways of impairing these host-pathogen interactions to facilitate clearance of infection.  These principles enable a targeted approach to infectious disease control in an era where the conservation of traditional antimicrobial treatments is paramount.  This central focus of my research includes biofilm and co-culture models, genomic and molecular analysis of gene expression to prove clinically relevant hypotheses.

Collaborations:  Universities of Warwick, University of Strathclyde, University of Bristol, Khon Kaen University (Thailand).

Supervision:  I have supervised one PhD to completion; I currently supervise three PhD students and co-supervise three PhD students.  I supervise MSc, MRes and BSc dissertation students projects as well as summer studentship research projects and ERASMUS placements

Selected publications
 

1. Taleb, H., Morris, R. K., Withycombe, C. E., Maddocks, S. E. and Kanekanian A. (2016) Date syrup polyphenols modulate angiogenic responses, VEGF and COX-2 expression in endothelial cells. Nutrition Research. In Press.
   
2. Taleb, H., Maddocks, S. E., Morris, R. K. and Kanekanian, A. (2016) The antibacterial activity of date syrup polyphenols against Staphylococcus aureus and Escherichia coli. Frontiers in Microbiology. In Press.
3. Johns, B. E., Purdy, K. J., Tucker, N. P. and Maddocks, S. E. (2015)  Phenotypic and genotypic characteristics of Small Colony Variants and their role in chronic infection.  Microbiology Insights 8: 15-13
4. Roberts, A. L., Maddocks, S. E., Cooper, R. A. (2015) Manuka honey reduces the motility of Pseudomonas aeruginosa by suppression of flagella-associated genes Journal of Antimicrobial Chemotherapy 70(3):716-25
5. Maddocks, S. E., Barbour, M. E. and Collins, A. M (2014) Nanoparticle technology to deliver effective antimicrobials American Journal of Microbiology 5: 35-36
6. Ripley, D. A., Morris, R. H. and Maddocks, S. E. (2014) Dual stimulation with bacterial and viral components increases the expression of hepcidin in human monocytes. FEMS Microbiology Letters 359: 161-165
7. Camplin, A. L and Maddocks S. E. (2014) Manuka honey treatment of biofilms of Pseudomonas aeruginosa results in the emergence of isolates with increased honey resistance. Annals of Clinical Microbiology and Antimicrobials 13:19
8. Wood, N.J., Maddocks, S. E., Grady, H. J., Collins, A. M. and Barbour, M. E. (2014) Functionalisation of ethylene vinyl acetate with antimicrobial chlorhexidine hexametaphosphate nanoparticles. International Journal of Nanomedicine 9: 4145-4152
9. Maddocks, S. E., Jenkins, R. E., Rowlands, R. S., Purdy, K. J and Cooper, R. A. (2013). Manuka honey inhibits adhesion and invasion of medically important wound bacteria.  Future Microbiology 8: 1523-1536.
10. Maddocks, S. E and Jenkins, R. E. (2013) Honey: a sweet solution to the growing problem of antimicrobial resistance? Future Microbiology 8: 1419-1429.
11. Barbour, M. E., Maddocks, S. E., Wood, N. J., Collins, A. M. (2013) Synthesis, characterisation and efficacy of antimicrobial chlorhexidine hexametaphosphate nanoparticles for applications in biomedical materials and consumer products. International Journal of Nanomedicine 8: 3507-3519
12. Franklin, L., Nobbs, A. H., Bricio-Moreno, L., Wright, C. J. Maddocks, S. E., Sahota, J. S., Ralph, J., O’Connor, M, Jenkinson, H. F. and Kadioglu, A. (2013). The AgI/II family adhesin AspA is required for respiratory infection by Streptococcus pyogenes.  PLoS One. 8: e62433
13. Kronda, J., Cooper, R. A. and Maddocks, S. E. (2013) Manuka honey inhibits siderophore production in Pseudomonas aeruginosa. Journal of Applied Microbiology 115: 86-90
14. Roberts A. E. L., Maddocks, S. E. and Cooper, R. A. (2012) Manuka honey is bactericidal against Pseudomonas aeruginosa and results in differential expression of oprF and algD. Microbiology 158: 3005-3013.
15. Green, A. E., Rowlands, R. S. Cooper, R. A. and Maddocks, S. E. (2012) The effect of the flavonol morin on adhesion and aggregation of Streptococcus pyogenes. FEMS Letters Microbiology. 333: 54-58
16. Maddocks, S. E., Salinas Lopez, M., Rowlands, R. S. and Cooper, R. A. (2012) Manuka honey inhibits the development of Streptococcus pyogenes biofilms and causes reduced expression of two fibronectin binding proteins. Microbiology. 158: 781-790
17. Maddocks, S. E., Wright, C. J.,  Nobbs, A. H.,  Brittan, J. L., Franklin,  L., Stromberg, N., Kadioglu, A.,  Jepson, M. A. and Jenkinson, H. F. (2011) Streptococcus pyogenes antigen I/II family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation. Molecular Microbiology. 81: 1034-1049​
    

• Member of the Royal Society of Biology
  
• Member of the Microbiology Society
  
• Fellow of the Institute of Biomedical Sciences
  
• Member of the Royal Society of Biology Membership Advisory Committee
  
• Member of the editorial board of “The Biologist”; published by Royal Society of Biology
  
• Member of the Microbiology Society Professional Development Committee
  
• Member of the Microbiology Society Prokaryotic Division
  
• Review Editor the Editorial Board of Frontiers in Cellular and Infection Microbiology
  

Twitter: @SarahMaddocks

Linked In: https://uk.linkedin.com/in/sarah-maddocks-1b740848​