My research is centred on the short-term and life-long effects of hypoxic exposure, with a particular focus on how the cardiovascular system adapts to high altitude. I am especially interested in the divergent pathways of adaptation taken by separate native high altitude populations, and establishing the mechanisms underpinning such differences. Recent work has diverged into other populations who experience hypoxia such as breath hold divers, and the pathophysiology of certain clinical conditions that present with hypoxemia.
My most recent research has focused on cardiac function in Himalayan Sherpa utilising novel echocardiographic imaging techniques both at rest and during exercise above 5000 m. This work will be continued with two future expeditions and expanded to other ethnicities native to high altitude.
Refereed Academic Journal Articles
Bain AR, Dujic Z, Hoiland RL, Barak OF, Madden D, Drvis I,
Stembridge M, Macleod DB, Macleod DM and Ainslie PN (2015). Peripheral chemoreflex inhibition with low-dose dopamine; new insight into mechanisms of extreme apnea. AJP Reg, Int and Com Phys. In Press.
Stembridge M, Ainslie PN and Shave R (2015). Mechanisms underlying reductions in stroke volume at rest and during exercise at high altitude. Eur J Spt Sci. In Press.
Stembridge M, Ainslie PN, Hughes MG, Stohr EJ, Cotter JD, Tymko MM, Day TA, Bakker A & Shave RE. (2015). Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude. J Appl Physiol (1985), JAP 00995 02014.
Stembridge M & Esformes JI. (2015). In vivo human cardiac shortening and lengthening velocity is region-dependent and not coupled with heart rate: 'Longitudinal' strain rate markedly underestimates apical contribution. Exp Physiol.
Utomi V, Oxborough D, Ashley E, Lord R, Fletcher S,
Stembridge M, Shave R, Hoffman MD, Whyte G, Somauroo J, Sharma S & George K. (2015). The impact of chronic endurance and resistance training upon the right ventricular phenotype in male athletes. Eur J Appl Physiol.
Hoiland RL, Foster GE, Donnelly J,
Stembridge M, Willie CK, Smith KJ, Lewis NC, Lucas SJ, Cotter JD, Yeoman DJ, Thomas KN, Day TA, Tymko MM, Burgess KR & Ainslie PN. (2014). Chemoreceptor responsiveness at sea level does not predict the pulmonary pressure response to high altitude. Chest.
Stembridge M, Ainslie PN, Hughes MG, Stohr EJ, Cotter JD, Nio AQ & Shave R. (2014). Ventricular structure, function and mechanics at high altitude: chronic remodelling in Sherpa verses short-term lowlander adaptation. J Appl Physiol (1985).
Tremblay JC, Lovering AT, Ainslie PN,
Stembridge M, Burgess KR, Bakker A, Donnelly J, Lucas SJ, Lewis NC, Dominelli PB, Henderson WR, Dominelli GS, Sheel AW & Foster GE. (2014). Hypoxia, not pulmonary vascular pressure induces blood flow through intrapulmonary arteriovenous anastomoses. J Physiol.
Foster GE, Ainslie PN,
Stembridge M, Day TA, Bakker A, Lucas SJ, Lewis NC, Macleod DB & Lovering AT. (2014). Resting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpas. J Physiol.
Lewis NC, Bailey DM, Dumanoir GR, Messinger L, Lucas SJ, Cotter JD, Donnelly J, McEneny J, Young IS,
Stembridge M, Burgess KR, Basnet AS & Ainslie PN. (2014). Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation. J Physiol.
Lord R, Somauroo J,
Stembridge M, Jain N, Hoffman MD, George K, Jones H, Shave R, Haddad F, Ashley E & Oxborough D. (2014). The right ventricle following ultra-endurance exercise: insights from novel echocardiography and 12-lead electrocardiography. Eur J Appl Physiol.
Stohr EJ, Meah VL &
Stembridge M. (2014). Combined neonatal therapies for cardiac function in adulthood - live together, die alone? J Physiol 592, 825-826.
Stone KJ, Hughes MG,
Stembridge MR, Meyers RW, Newcombe DJ & Oliver JL. (2014). The influence of playing surface on physiological and performance responses during and after soccer simulation. Eur J Sport Sci, 1-8.
Utomi V, Oxborough D, Ashley E, Lord R, Fletcher S,
Stembridge M, Shave R, Hoffman MD, Whyte G, Somauroo J, Sharma S & George K. (2014). Predominance of normal left ventricular geometry in the male 'athlete's heart'. Heart 100, 1264-1271.
Hughes MG, Birdsey L, Meyers R, Newcombe D, Oliver JL, Smith PM,
Stembridge M, Stone K & Kerwin DG. (2013). Effects of playing surface on physiological responses and performance variables in a controlled football simulation. J Sports Sci 31, 878-886.
Stone, K.J., Oliver, J.L., Hughes, M.G., Stembridge, M.R., Newcombe, D.J. & Meyers, R.W. (2011). Development of a soccer simulation protocol to include repeated sprints and agility. International Journal of Sports Physiology and Performance.
Turner, A, Walker, S,
Stembridge, M, Coneyworth, P, Reed, G, Birdsey, L, Barter, P, Moody, J (2011). Testing Battery for the Assessment of Fitness in Soccer Players. Strength & Conditioning Journal: 33 (5), 29-39.
Oliver, J and
Stembridge, M (2011). Use of a heart rate:ground contact index to monitor and predict middle distance running. European Journal of Sport Science. 11 (6), 431-436.
Stembridge M, Ainslie PN & Shave R. (2014). Short-term adaptation and chronic cardiac remodelling to high altitude in lowlander natives and Himalayan Sherpa. Exp Physiol.
I have presented as part of symposia and submitted over 25 conference abstracts to both national and international conferences.